Now on the run, Picard and the skeleton crew of the U.S.S. Titan must break into Starfleet's most top-secret facility to expose a plot that could destroy the Federation. Picard must turn to the only soul in the galaxy who can help — an old friend.

Patrick Stewart (Admiral Jean-Luc Picard)
Jeri Ryan (Commander Seven of Nine)
Michelle Hurd (Commander Raffi Musiker)
Ed Speleers (Jack Crusher)

LeVar Burton (Commodore Geordi La Forge)
Michael Dorn (Captain Worf)
Jonathan Frakes (Captain William T. Riker)
Gates McFadden (Dr. Beverly Crusher)
Marina Sirtis (Deanna Troi)
Brent Spiner (Daystrom Android M-5-10)
Daniel Davis (Professor James Moriarty)

Todd Stashwick (Captain Liam Shaw)
Amanda Plummer (Captain Vadic)
Ashlei Sharpe Chestnut (Ensign Sidney La Forge)

Mica Burton (Ensign Alandra La Forge)
Stephanie Czajkowski (Lieutenant T'Veen)
Joseph Lee (Lt. Matthew Arliss Mura)
Jin Maley (Ensign Kova Rin Esmar)
Amy Earhart (U.S.S. Titan Computer)
Vaugh Page (Shrike Bridge Changeling)
Byron Quiros (Starfleet Lieutenant)

• After telling Beverly about his waking nightmares, Beverly diagnoses Jack with irumodic syndrome, which is what ultimately killed Picard.
  
• Raffi, Worf, and Riker use the key they received from Krinn to enter the Daystrom Institute facility, which is protected by an advanced A.I. The Daystrom A.I. is "Daystrom Android M-5-10", the last android built by Dr. Altan Inigo Soong before he died. The new Android is a golem modeled after Dr. Soong's appearance, and integrates the personalities of Data, B4, Lore, and Lal.
  
• Upon recognizing Will Riker, the A.I. dispatches a crow and a holographic Professor James Moriarty while playing disjointed music.
  
• Riker recognizes the music as "Pop Goes The Weasel" and there is a flashback to him meeting Data in "Encounter At Farpoint".
  
• Moriarty last appeared in the Next Generation season 6 episode "Ship in a Bottle".
  
• The Starfleet Fleet Museum at Athan Prime is run by Commodore Geordi La Forge. His younger daughter Alandra is stationed there with him.
  
• Several historic ships are shown on screen including: the U.S.S. Defiant NX-74205, U.S.S. Enterprise NCC-1701-A, U.S.S. Voyager NCC-74656, and the Klingon bird of prey H.M.S. Bounty from Star Trek III: The Search For Spock and Star Trek IV: The Voyage Home.
  
• Amongst the items shown at Daystrom Institute are the Genesis Device from Star Trek II: The Wrath Of Khan, a genetically modified Tribble, and the remains of James T Kirk.
  
• The Data/Lore/Daystrom android reveals the changelings stole the remains of Jean-Luc Picard.
  
• Jack and Sidney steal the cloaking device from the Bounty and attempt to integrate it into the U.S.S. Titan's systems.
  
• Vadic captures Riker and takes him prisoner on The Shrike, where Deanna Troi is imprisoned.
  
• Mica Burton (Ensign Alandra La Forge) is LeVar Burton's daughter in real life.
  
• Stephanie Czajkowski (Lt. T'Veen) and Jin Maley (Ensign Esmar) appear in the end credits, but have no speaking lines in the aired episode.