After reuniting with what remains of Starfleet and the Federation, the U.S.S. Discovery and its crew must prove that a 930 year old crew and starship are exactly what this new future needs.

Sonequa Martin-Green (Commander Michael Burnham)
Doug Jones (Captain Saru)
Anthony Rapp (Lt. Cmdr. Paul Stamets)
Mary Wiseman (Ensign Sylvia Tilly)
Wilson Cruz (Dr. Hugh Culber)
Rachael Ancheril (Commander Nhan)

Michelle Yeoh (Philippa Georgiou)

Oded Fehr (Admiral Charles Vance)
Blu del Barrio (Adira Tal)
David Cronenberg (Kovich)
Tig Notaro (Commander Jett Reno)

Emily Coutts (Lt. Keyla Detmer)
Patrick Kwok-Choon (Lt. Gen Rhys)
Oyin Oladejo (Lt. Joann Owosekun
Ronnie Rowe Jr. (Lt. Ronald Bryce)
Sara Mitich (Lt. Nilsson)
Julianne Grossman (Discovery Computer)
Brendan Beiser (Dr. Eli the EMH)
Jake Epstein (Dr. Attis)
Vanessa Jackson (Lt. Audrey Willa)
Ana Sani (Mom)
Ava MacKinnon (Daughter #1)
Shazdeh Kapadia (Daughter #2)
RJ Parrish (Holo Security Officer #1)
Vanessa Burns (Holo Security Officer #2)
Chris Zamat (Holo Officer #1)
Jajube Mandiela (Holo Officer #2)
Daniel Woodrow (Holo Officer #3)
Shannon Lahaie (Tactical Officer)
Rosie Simon (Starfleet Ensign)

• A starbase houses both Federation and Starfleet headquarters. An energy shield surrounds the starbase. UFP membership is down to 38 member worlds, from a peak of 350.
  
• Saru's homeworld Kaminar joined the Federation at some point, though Starfleet lost contact with the Kelpians after The Burn.
  
• In order to create a cure for the Kili, the U.S.S. Discovery jumps to the U.S.S. Tikhov NCC-1067-M, which contains a galactic seed vault. Federation worlds take turns taking care of the vault. The current caretakers of the Tikhov were Barzan, a family of four. The Barzans joined the Federation in the 25th century.
  
• During her debriefing, we learn that Nhan's first name starts with D. She remains aboard the U.S.S. Tikhov with Dr. Attis to take the ship back to Barzan and complete its mission.
  
• The 11th generation U.S.S. Voyager NCC-74656-J is shown at Starfleet HQ.
  
• Among the ships at starbase is the U.S.S. Nog NCC-325070, confirmed to be Eisenberg-class by the production crew. This is a tribute to DS9 actor Aron Eisenberg, who passed away in 2019.