With the secret of his genetically-engineered past out in the open, Dr. Bashir is asked to work with a group of others like him. Aggressive Jack, sensual Lauren, giddy Patrick, and shy Sarina are highly intelligent—but equally dysfunctional—and have spent their lives in an institution. It is hoped that Bashir can help them assimilate into "normal" society, and while he is initially put off by their antisocial behavior, Bashir is excited by the prospect of helping them succeed. Soon, these "mutants" take interest in the Dominion conflict and make some very interesting predictions for things to come.

Jeffrey Combs (Weyoun)
Tim Ransom (Jack)
Hilary Shepard-Turner (Lauren)
Michael Keenan (Patrick)
Casey Biggs (Gul Damar)
Jeannetta Arnette (Dr. Loews)
Faith C. Salie (Sarina)

• Gul Damar takes Gul Dukat's place as the head of the Cardassian government.
  
• Bashir was exposed as genetically-enhanced in the episode "Doctor Bashir, I Presume".
  
• Hillary Shepard also played Hoya in the 5th season episode "The Ship".
  
• Michael Keenan also played Governor Maturin in the TNG episode "Sub Rosa".